In the end, the choice mostly depends on what you want the bullet to do. With bullets of similar construction, you can generally expect the heavy bullet to penetrate deeper and the lighter bullet to destroy more tissue. Comparing this week's 180-grain Remington JHP bullet to last week's 155-grain JHP offering, this axiom is perfectly illustrated. The wound cavity created by the 180-grain bullet was narrower, but the heavier bullet penetrated about 29 percent deeper.
| Load | MV (fps) | PEN (inches) | EXP (inches) | RW (grains) |
| .40 S&W Remington 180-grain JHP | 957 | 16.75 | .61 | 180 |
